The Moon will turn a rusty hue in the early hours of Monday and may seem larger in the sky.
The event is caused by a total lunar eclipse coinciding with another astronomical event called a supermoon.
It's the second total lunar eclipse this year, but the first since 2008 where the whole eclipse will be visible from the UK.
The moon may look rust-coloured during a total lunar eclipse - giving rise to its nickname Blood Moon. This is because the Earth's atmosphere scatters blue light more strongly than red light, and it is this red light that reaches the lunar surface.
The eclipse will start at 01:11 BST early tomorrow morning, when the Moon enters the lightest part of the Earth's shadow, known as the penumbra, and adopts a yellowish colour. At 03:11 BST, the Moon completely enters the umbra - the inner dark corpus of our planet's shadow.
The point of greatest eclipse occurs at 03:47 BST, when the Moon is closest to the centre of the umbra. The sky show is over by 05:22 in the morning on Monday.