A battling Dan Evans could not take his surprise US Open run into the second week as he lost to Spanish 19th seed Tommy Robredo in four sets.
The Briton, 23, had two set points on his own serve to force a decider but could not convert, and Robredo won the third-round match 7-6 (8-6) 6-1 4-6 7-5 in three hours and 13 minutes.
Robredo, who struggled with a leg injury in the closing stages, fought back superbly from 5-3 down in the fourth set to claim victory.